Monday February 19th 2018

Accelerated repair of demyelinated CNS lesions in the absence of non‐muscle myosin IIB

The oligodendrocyte (OL), the myelinating cell of the central nervous system, undergoes dramatic changes in the organization of its cytoskeleton as it differentiates from a precursor (oligodendrocyte precursor cells) to a myelin‐forming cell. These changes include an increase in its branching cell processes, a phenomenon necessary for OL to myelinate multiple axon segments. We have previously shown that levels and activity of non‐muscle myosin II (NMII), a regulator of cytoskeletal contractility, decrease as a function of differentiation and that inhibition of NMII increases branching and myelination of OL in coculture with neurons. We have also found that mixed glial cell cultures derived from NMIIB knockout mice display an increase in mature myelin basic protein‐expressing OL compa…

Continue at source:  

Accelerated repair of demyelinated CNS lesions in the absence of non‐muscle myosin IIB

Leave a Comment

More from category

What side effects can result from interferon?
What side effects can result from interferon?

Interferon is used to treat several health conditions, but it has a range of side effects. We look at how these vary in [Read More]

FDA Clears Higher-Dose Glatopa Generic for MS FDA Clears Higher-Dose Glatopa Generic for MS
FDA Clears Higher-Dose Glatopa Generic for MS FDA Clears Higher-Dose Glatopa Generic for MS

Glatopa 40 mg/mL joins already-approved Glatopa 20 mg/mL, a glatiramer acetate generic for treatment of relapsing forms [Read More]

DIY faecal transplants carry risks including HIV and hepatitis, warn experts
DIY faecal transplants carry risks including HIV and hepatitis, warn experts

Faecal transplants have been used in medical settings to tackle superbugs, but following YouTube videos at home is too [Read More]

High blood pressure drug may also help prevent onset of type 1 diabetes
High blood pressure drug may also help prevent onset of type 1 diabetes

A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 [Read More]

Eye and balance exercises may ease multiple sclerosis symptoms
Eye and balance exercises may ease multiple sclerosis symptoms

Reuters Health - People with multiple sclerosis who do balance and eye movement exercises may feel steadier on their [Read More]