Friday January 19th 2018

Anti‐myelin antibodies play an important role in the susceptibility to develop proteolipid protein‐induced experimental autoimmune…

Summary Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. It is an autoimmune disorder in which activated T cells cross the blood–brain barrier (BBB) to initiate an inflammatory response that leads to demyelination and axonal damage. The key mechanisms responsible for disease initiation are still unknown. We addressed this issue in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. It is widely known that EAE manifests only in certain strains when immunized with myelin proteins or peptides. We studied the differential immune responses induced in two mouse strains that are susceptible or resistant to EAE induction when they are immunized with the 139–151 peptide of proteolipid protein, an encephalitogenic peptide capabl…

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Anti‐myelin antibodies play an important role in the susceptibility to develop proteolipid protein‐induced experimental autoimmune…

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