Saturday December 16th 2017

Diffusion tensor MRI alterations of subcortical deep gray matter in clinically isolated syndrome

Abstract: Background: Abnormalities in the gray matter (GM) of the brain parenchyma are present early in the course of multiple sclerosis.Objectives: To quantify white matter (WM) and subcortical deep GM (SDGM) alterations in patients with clinically isolated syndrome (CIS) using diffusion tensor imaging (DTI).Materials and methods: 45 CIS patients and 52 healthy controls (HC) were scanned on 3T MRI. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated, in addition to the estimation of structural brain volume and lesion measurements.Results: FA was significantly lower in CIS patients in the whole brain (p (Source: Journal of the Neurological Sciences)

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Diffusion tensor MRI alterations of subcortical deep gray matter in clinically isolated syndrome

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