Friday January 19th 2018

Effect of Estrogen on Th1, Th2 and Th17 Cytokines Production by Proteolipid Protein and PHA Activated Peripheral Blood Mononuclear Cells Isolated from…

In this study we evaluated the effect of E2 on the synthesis of inflammatory, antiinflammatory and regulatory cytokines.Methods: We analyzed the effect of E2 on IL-4, IL-10, IL-17, TNF-α and IFN-γ cytokines produced by proteolipid protein (PLP) or mitogen phytohemagglutinin (PHA)-activated peripheral blood mononuclear cells isolated from multiple sclerosis patients in comparison to healthy control group. We used RT-PCR and ELISA to detect the level of cytokines.Results: We found that E2 significantly increased IL-10 expression and secretion and decreased expression of TNF-α in both groups and IL-4 in patients in cells stimulated with PLP or PHA (p  (Source: Archives of Medical Research)

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Effect of Estrogen on Th1, Th2 and Th17 Cytokines Production by Proteolipid Protein and PHA Activated Peripheral Blood Mononuclear Cells Isolated from…

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