Monday February 19th 2018

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

In this study, we investigated the therapeutic efficacy of an inhibitor of the immunoproteasome (ONX 0914) in two different mouse models of MS. ONX 0914 attenuated disease progression after active and passive induction of experimental autoimmune encephalomyelitis (EAE), both in MOG35–55 and PLP139–151‐induced EAE. Isolation of lymphocytes from the brain or spinal cord revealed a strong reduction of cytokine‐producing CD4+ cells in ONX 0914 treated mice. Additionally, ONX 0914 treatment prevented disease exacerbation in a relapsing‐remitting model. An analysis of draining lymph nodes after induction of EAE revealed that the differentiation to Th17 or Th1 cells was strongly impaired in ONX 0914 treated mice. These results implicate the immunoproteasome in the development of EAE and…

View original:

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

Leave a Comment

More from category

What side effects can result from interferon?
What side effects can result from interferon?

Interferon is used to treat several health conditions, but it has a range of side effects. We look at how these vary in [Read More]

FDA Clears Higher-Dose Glatopa Generic for MS FDA Clears Higher-Dose Glatopa Generic for MS
FDA Clears Higher-Dose Glatopa Generic for MS FDA Clears Higher-Dose Glatopa Generic for MS

Glatopa 40 mg/mL joins already-approved Glatopa 20 mg/mL, a glatiramer acetate generic for treatment of relapsing forms [Read More]

DIY faecal transplants carry risks including HIV and hepatitis, warn experts
DIY faecal transplants carry risks including HIV and hepatitis, warn experts

Faecal transplants have been used in medical settings to tackle superbugs, but following YouTube videos at home is too [Read More]

High blood pressure drug may also help prevent onset of type 1 diabetes
High blood pressure drug may also help prevent onset of type 1 diabetes

A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 [Read More]

Eye and balance exercises may ease multiple sclerosis symptoms
Eye and balance exercises may ease multiple sclerosis symptoms

Reuters Health - People with multiple sclerosis who do balance and eye movement exercises may feel steadier on their [Read More]