Wednesday October 18th 2017

Injury to a specific neural pathway detected by ultra-high-field MRI

We present evidence for the potential of ultra-high-field MRI to reveal injury due to multiple sclerosis (MS) not appreciated using lower field imaging. Internuclear ophthalmoplegia (INO) is an eloquent ocular motor syndrome that frequently affects patients with MS. The medial longitudinal fasciculus (MLF) is a periventricular, dorsomedial brainstem tegmentum pathway that yokes the 2 eyes in many types of eye movements.1,2 Further, T2 lesions localized in the region containing the MLF strongly associate with INO.3 However, the small diameter of the MLF and lack of contrast between the MLF and the surrounding neural tissue on conventional MRI hinder direct visualization.4 We recently demonstrated that the MLF is clearly visible on T2*-weighted images at 7T among healthy controls.4 In this c…

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Injury to a specific neural pathway detected by ultra-high-field MRI

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