Tuesday September 19th 2017

Innate Mucosal‐Associated Invariant T (MAIT) cells are activated in Inflammatory Bowel Diseases

Abstract Inflammatory Bowel Diseases are characterized by a deregulated immune response targeting the gut bacterial flora. Mucosal‐Associated Invariant T (MAIT) cells are MHC class Ib‐restricted innate‐like lymphocytes with anti‐bacterial functions. They display an effector/memory phenotype and are found in large numbers in the blood, mucosae and liver. They also have been implicated in inflammatory diseases such as multiple sclerosis. Therefore, we aimed at analyzing the possible involvement of MAIT cells in Crohn’s Disease (CD) and Ulcerative Colitis (UC). To this end, a phenotypic and functional analysis of MAIT cells isolated from the blood of healthy subjects, CD and UC patients was undertaken. MAIT cells were also quantified in ileal biopsies of CD patients. The frequency of …

View this article: 

Innate Mucosal‐Associated Invariant T (MAIT) cells are activated in Inflammatory Bowel Diseases

Leave a Comment

More from category

Scientists discover markers for progressive multiple sclerosis
Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- [Read More]

Study uncovers markers for severe form of multiple sclerosis
Study uncovers markers for severe form of multiple sclerosis

Scientists have uncovered two molecules involved in cell communication and movement that may explain why some people [Read More]

Costly drugs to weigh on U.S. employers’ expenses in 2018: survey
Costly drugs to weigh on U.S. employers’ expenses in 2018: survey

(Reuters) - U.S. employers are bracing for higher health care expenses in 2018 as spending on new drugs to treat [Read More]

TG Therapeutics commences enrolment for Phase III multiple sclerosis trials
TG Therapeutics commences enrolment for Phase III multiple sclerosis trials

US-based biopharmaceutical firm TG Therapeutics has commenced enrolment for the Phase III ULTIMATE clinical programme [Read More]

Therapy could offer new hope for MS patients
Therapy could offer new hope for MS patients

Multiple sclerosis sufferer Roy Palmer and his wife Helen (pictured) are desperate for him to be able to walk again. [Read More]