Saturday August 19th 2017

Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis.

Authors: Karakas Celik S, Oz ZS, Dursun A, Unal A, Emre U, Cicek S, Keni FM Abstract Proinflammatory cytokines with immunosuppressive properties play an important role in the pathogenesis of multiple sclerosis (MS). Interleukin 18 (IL-18) is one of the most important innate cytokines produced from macrophages in the early stages of the inflammatory immune response. The purpose of this study was to determine whether there was any relationship between IL18 gene polymorphisms and MS. IL18 genotyping were performed in 101 MS patients and 164 control subjects by using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. The frequency of MS patients with the CC genotype of the IL18 gene at position -137 was significantly higher than with the GG genotype [p = 0.01, odds r…

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Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis.

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