Sunday November 19th 2017

Intrathecal immune reset in multiple sclerosis: Exploring a new concept

This article examines the consequences of this intrathecal response: giving a worst clinical prognostic value and bearing arguments for possible direct brain toxicity, intrathecal secretion should be targeted by drugs abating both B-lymphocytes and plasma cells. Another consequence is that intrathecal secretion has value as a surrogate marker of the persistence of an ongoing intrathecal immune reaction after treatment. Although it is still unsure which mechanism or byproduct secreted by TLO triggers cortical lesions, we propose to target TLO components as a new therapeutic avenue in progressive MS.Whereas it was long considered that the inability of therapies to penetrate the blood–brain-barrier was a crucial obstacle, our proposed strategy will take advantage of the properties of the BB…

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Intrathecal immune reset in multiple sclerosis: Exploring a new concept

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