Monday February 19th 2018

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

Conclusions: Together our results indicate that the alternative activation status of macrophages promotes their migratory properties to chemoattractants relevant for neuroinflammatory diseases like MS. Conversely, classically activated, proinflammatory macrophages have reduced migratory properties. Based on our results, we postulate that the activation status of the macrophage influences the capacity of the macrophages to rearrange their cytoskeleton. This is the first step in understanding how modulation of macrophage activation affects macrophage migration in neuroinflammatory diseases like MS. (Source: Journal of Neuroinflammation)

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Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

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