Monday February 19th 2018

Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate

Myelinogenesis in the mammal nervous system occurs predominantly postnatally. Glatiramer acetate (GA), a drug for the treatment for multiple sclerosis (MS), has been shown to induce immunomodulation and neuroprotection in the inflamed CNS in MS and in experimental autoimmune encephalomyelitis (EAE). Here we investigated whether GA can affect myelinogenesis and oligodendrogenesis in the developing nervous system under nonpathological conditions. Towards this end we studied myelination in mice injected daily by GA, at postnatal Days 7–21. Immunohistological and ultrastructural analyses revealed significant elevation in the number of myelinated axons as well as in the thickness of the myelin encircling them and their resulting g‐ratios, in spinal cords of GA‐injected mice compared with …

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Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate

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