Monday December 18th 2017

Relapses in multiple sclerosis: effects of high‐dose steroids on cortical excitability

ConclusionsVery rapid functional changes in the excitability of cortical circuits involved in motor control can be induced by steroids, before any process of remyelination or axonal regeneration has time to occur. The net effect of steroids on the balance between intracortical GABAergic inhibition and glutamatergic facilitation was in favour of weaker inhibition or stronger facilitation, which could lead to improving the motor performance in MS patients. (Source: European Journal of Neurology)

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Relapses in multiple sclerosis: effects of high‐dose steroids on cortical excitability

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