Thursday January 18th 2018

SIRT1 is decreased during relapses in patients with multiple sclerosis.

Authors: Tegla CA, Azimzadeh P, Andrian-Albescu M, Martin A, Cudrici CD, Trippe R, Sugarman A, Chen H, Boodhoo D, Vlaicu SI, Royal W, Bever C, Rus V, Rus H Abstract SIRT1 is a member of the histone deacetylase (HDAC) class III family of proteins and is an NAD-dependent histone and protein deacetylase. SIRT1 can induce chromatin silencing through the deacetylation of histones and can modulate cell survival by regulating the transcriptional activities. We investigated the expression of SIRT1 in multiple sclerosis (MS) brains and in peripheral blood mononuclear cells (PBMCs) obtained from patients with relapsing-remitting multiple sclerosis. We found that SIRT1 was expressed by a significant number of cells in both acute and chronic active lesions. We also found that CD4(+), CD68(+), …

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SIRT1 is decreased during relapses in patients with multiple sclerosis.

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