Saturday August 19th 2017

Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes with 5-fluorouracil and Prolongs Survival in a CT26 Syngeneic Murine Colon Cancer…

While the 5 year survival rate of colorectal cancer is 65%, the 5 year survival of patients with distant metastasis is only 5%. Recently, prognosis of patients with liver or lung metastasis has improved, but remains dismal in peritoneal carcinomatosis (PC) patients. Although treatment with 5-fluorouracil (5-FU) is not effective for PC, 5-FU remains the drug of choice to use in combination with other drugs to elicit synergistic inhibitory effects on colon cancer. The FDA approved drug for treatment of multiple sclerosis, FTY720, is a functional antagonist of S1P receptor 1 that disrupts signaling by sphingosine-1-phosphate (S1P), a bioactive lipid mediator that plays critical roles in cancer progression. The aim of this study was to evaluate the potential of FTY720, which we have previously…

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

View original article – 

Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes with 5-fluorouracil and Prolongs Survival in a CT26 Syngeneic Murine Colon Cancer…

Leave a Comment

More from category

Researchers Co-funded by National MS Society Report on New Way to Translate Lab Findings Aimed at Re
Researchers Co-funded by National MS Society Report on New Way to Translate Lab Findings Aimed at Re

/About-the-Society/News/Researchers-Co-funded-by-National-MS-Society-Repor [Read More]

Investigators Recruiting for Study of ALKS 8700 vs. Dimethyl Fumarate in Relapsing-Remitting MS
Investigators Recruiting for Study of ALKS 8700 vs. Dimethyl Fumarate in Relapsing-Remitting MS

/About-the-Society/News/Investigators-Recruiting-for-Study-of-ALKS-8700-vs [Read More]

Statement on House Oversight and Government Reform Committee Action on the Pricing Strategies for MS
Statement on House Oversight and Government Reform Committee Action on the Pricing Strategies for MS

/About-the-Society/News/Statement-on-House-Oversight-and-Government-Reform [Read More]

Drug blocked by regulators found to improve quality of life for MS patients
Drug blocked by regulators found to improve quality of life for MS patients

A drug that is blocked by the EU regulatory system has now been found to improve the quality of life of people with [Read More]

House Dems launch MS drug pricing probe
House Dems launch MS drug pricing probe

Democrats from the House Committee on Oversight and Government Reform have sent letters to seven drugmakers as part of [Read More]