Thursday January 18th 2018

Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes with 5-fluorouracil and Prolongs Survival in a CT26 Syngeneic Murine Colon Cancer…

While the 5 year survival rate of colorectal cancer is 65%, the 5 year survival of patients with distant metastasis is only 5%. Recently, prognosis of patients with liver or lung metastasis has improved, but remains dismal in peritoneal carcinomatosis (PC) patients. Although treatment with 5-fluorouracil (5-FU) is not effective for PC, 5-FU remains the drug of choice to use in combination with other drugs to elicit synergistic inhibitory effects on colon cancer. The FDA approved drug for treatment of multiple sclerosis, FTY720, is a functional antagonist of S1P receptor 1 that disrupts signaling by sphingosine-1-phosphate (S1P), a bioactive lipid mediator that plays critical roles in cancer progression. The aim of this study was to evaluate the potential of FTY720, which we have previously…

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Sphingosine-1-phosphate Receptor Modulator, FTY720, Synergizes with 5-fluorouracil and Prolongs Survival in a CT26 Syngeneic Murine Colon Cancer…

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