Monday February 19th 2018

Targeting the Sphingosine-1-phosphate Signaling with FTY720 in Obesity Related Breast Cancer Progression

In this study, we found that obesity in animal breast cancer models increases SphK1 and levels of S1P in both tumor and its microenvironment. To examine the contribution of increased S1P to breast cancer progression and metastasis, mice were treated with FTY720 to disrupt the S1P signaling, which is strengthened by obesity. (Source: Journal of Surgical Research)

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Targeting the Sphingosine-1-phosphate Signaling with FTY720 in Obesity Related Breast Cancer Progression

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