Monday February 19th 2018

Therapeutic effect of anti-αv integrin mAb on Theiler’s murine encephalomyelitis virus-induced demyelinating disease

We examined the regulatory role of αv integrins in the development of Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model of multiple sclerosis (MS). Blockade of αv integrins by anti-αv integrin monoclonal antibody (mAb) in the effector phase significantly suppressed the development of TMEV-IDD both clinically and histologically. The number of infiltrating mononuclear cells (MNCs) in the CNS was significantly decreased in mice treated with anti-αv integrin mAb. Flow cytometric analysis of cytokine staining revealed that absolute numbers of IFN-γ- and IL-17-producing CD4+ and IFN-γ-producing CD8+ T cells were significantly decreased in the CNS of mice treated with anti-αv integrin mAb. These data suggest that αv integrins may play important rol…

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Therapeutic effect of anti-αv integrin mAb on Theiler’s murine encephalomyelitis virus-induced demyelinating disease

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