Tuesday September 19th 2017

Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab

We report the first case of combined retinal and CNS varicella zoster-associated vasculitis in a 49-year-old patient with multiple sclerosis who had been treated with natalizumab. He presented with a progressive bilateral visual loss. The diagnosis of a vasculitis was based on the fundoscopic examination and MRI findings. We confirmed the varicella zoster virus (VZV) infection of the CNS by PCR and increased intrathecal antibody indices in the cerebrospinal fluid. The patient was stabilized with antiviral treatment, methylprednisolone, plasmapheresis and cycophosphamide. Natalizumab was discontinued. This case illustrates the neuroimmunological and neuroinfectiological consequences of treatments with biologicals that influence the immune system. (Source: Journal of Neuroinflammation)

Continued here: 

Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab

Leave a Comment

More from category

Scientists discover markers for progressive multiple sclerosis
Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- [Read More]

Study uncovers markers for severe form of multiple sclerosis
Study uncovers markers for severe form of multiple sclerosis

Scientists have uncovered two molecules involved in cell communication and movement that may explain why some people [Read More]

Costly drugs to weigh on U.S. employers’ expenses in 2018: survey
Costly drugs to weigh on U.S. employers’ expenses in 2018: survey

(Reuters) - U.S. employers are bracing for higher health care expenses in 2018 as spending on new drugs to treat [Read More]

TG Therapeutics commences enrolment for Phase III multiple sclerosis trials
TG Therapeutics commences enrolment for Phase III multiple sclerosis trials

US-based biopharmaceutical firm TG Therapeutics has commenced enrolment for the Phase III ULTIMATE clinical programme [Read More]

Therapy could offer new hope for MS patients
Therapy could offer new hope for MS patients

Multiple sclerosis sufferer Roy Palmer and his wife Helen (pictured) are desperate for him to be able to walk again. [Read More]