Monday May 29th 2017

Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE.

Authors: Levy-Barazany H, Barazany D, Puckett L, Kanfi S, Borenstein-Auerbach N, Yang K, Peron JP, Weiner HL, Frenkel D Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) considered to be a T cell-mediated autoimmune disease. Mucosally administered antigens induce regulatory T cells that secrete anti-inflammatory cytokines at the anatomic site where the mucosally administered Ag is located. We have previously reported in a mouse model of stroke that nasal treatment with MOG35-55 peptide reduces ischemic infarct size and improves behavior, by inducing IL-10-secreting T cells. We have also demonstrated that an experimental autoimmune encephalomyelitis (EAE) model in non-obese diabetic (NOD) mice leads to a relapsing progressive dise…

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Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE.

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