Monday February 19th 2018

Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction

Antiphospholipid syndrome (APS) is a rare autoimmune coagulopathy with various systemic and neurologic symptoms. Ischemic stroke and TIA are common neurologic manifestations of APS, while migraine, epilepsy, chorea, and multiple sclerosis–like syndromes have also been reported.1,2 Dementia is an unusual manifestation of APS, and the presentation of APS with corticobasal syndrome (CBS) has rarely been reported.3,4 CBS is a progressive neurologic syndrome characterized by asymmetric cortical dysfunction, such as apraxia, alien limb phenomenon, or cortical sensory changes accompanied by akineto-rigid syndrome or dystonia.5,6 Cognitive dysfunction is not uncommon in this disease. The underlying pathologies of CBS, which include corticobasal degeneration (CBD), Alzheimer disease, Pick dis…

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Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction

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