Wednesday July 26th 2017

Expression of a single ICAM‐1 isoform on T cells is sufficient for development of experimental autoimmune encephalomyelitis

In this study, we show using a newly developed transgenic mouse (CD2‐Icam1D4del/Icam1null) that T‐cell‐specific expression of a single ICAM‐1 isoform composed of Ig domains 1, 2, 3, and 5 can mediate the initiation and progression of EAE. Our results indicate that the ICAM‐1 isoform lacking Ig domain 4 can drive pathogenesis in demyelinating disease and may be a novel therapeutic target for treating multiple sclerosis. (Source: European Journal of Immunology)

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Expression of a single ICAM‐1 isoform on T cells is sufficient for development of experimental autoimmune encephalomyelitis

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