Wednesday October 18th 2017

G protein‐coupled receptor kinase 2 moderates recruitment of THP‐1 cells to the endothelium by limiting histamine‐invoked Weibel‐Palade body…

ConclusionsG protein‐coupled receptor kinase 2 deficiency in endothelial cells results in increased pro‐inflammatory signaling and enhanced leukocyte recruitment to activated endothelial cells. The ability of GRK2 to modulate initiation of inflammatory responses in endothelial cells as well as leukocytes now places GRK2 at the apex of control of this finely balanced process. (Source: Journal of Thrombosis and Haemostasis)

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G protein‐coupled receptor kinase 2 moderates recruitment of THP‐1 cells to the endothelium by limiting histamine‐invoked Weibel‐Palade body…

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