Monday May 29th 2017

Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases.

Conclusions: In addition to autoantigens implicated in thyroid autoimmunity, fibrocytes and derivative fibroblasts express multiple autoantigens associated with T1DM. This expression results from active gene promoters and abundant steady-state mRNA encoding ICA69 and IA-2. These latest findings demonstrate that fibrocytes express antigens relevant to multiple forms of endocrine autoimmunity. They suggest the potential for these cells playing a direct role in immune reactivity directed at the thyroid and pancreatic islets. PMID: 24517144 [PubMed – as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

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Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases.

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