Tuesday July 25th 2017

Identification of a novel Parkinson’s disease locus via stratified genome-wide association study

Conclusions: We discovered and replicated a new locus for Sporadic-PD which had escaped detection in un-stratified GWAS. This demonstrates that by stratifying on a key variable the power gained due to diminished heterogeneity can sometimes outweigh the power lost to reduced sample size. We also detected distinct patterns of disease associations for previously established PD susceptibility genes, which gives an insight to the genetic architecture of the disease and could aid in the selection of appropriate study population for future studies. (Source: BMC Genomics – Latest articles)

Original article – 

Identification of a novel Parkinson’s disease locus via stratified genome-wide association study

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