Friday January 19th 2018

Label‐fusion‐segmentation and deformation‐based shape analysis of deep gray matter in multiple sclerosis: The impact of thalamic subnuclei on…

Abstract Deep gray matter (DGM) atrophy has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and progresses throughout the disease course. We studied DGM volume and shape and their relation to disability in a large cohort of clinically well‐described MS patients using new subcortical segmentation methods and shape analysis. Structural 3D magnetic resonance images were acquired at 1.5 T in 118 patients with relapsing remitting MS. Subcortical structures were segmented using a multiatlas technique that relies on the generation of an automatically generated template library. To localize focal morphological changes, shape analysis was performed by estimating the vertex‐wise displacements each subject must undergo to deform to a template. Multipl…

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Label‐fusion‐segmentation and deformation‐based shape analysis of deep gray matter in multiple sclerosis: The impact of thalamic subnuclei on…

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