Tuesday July 25th 2017

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s disease

Conclusions: Increase in microglia’s CD163 immunoreactivity was more significant in AD than PD, and association of CD163 immunoreactive microglia with Abeta plaques indicate microglia’s attraction towards extracellular protein pathology, i.e. extracellular aggregates of Abeta as compared to intracellular Lewy Bodies in PD. Double staining with CD163 and CD68 might point towards their natural inclination to phagocytose plaques. Fibrinogen leakage and compromise of the blood brain barrier raise the possibility that these are not resident microglia, but systemic macrophages infiltrating the brain. (Source: Epidemiologic Perspectives and Innovations)

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Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s disease

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