Tuesday July 25th 2017

Sulfatide‐mediated control of extracellular matrix‐dependent oligodendrocyte maturation

In the central nervous system, the extracellular matrix (ECM) compound laminin‐2, present on developing axons, is essential in regulating oligodendrocyte (OLG) maturation. For example, laminin‐2 is involved in mediating interactions between integrins and growth factors, initially localizing in separate membrane microdomains. The galactosphingolipid sulfatide is an important constituent of these microdomains and may serve as a receptor for laminin‐2. Here, we investigated whether sulfatide interferes with ECM–integrin interactions and, in this manner, modulates OLG maturation. Our data reveal that disruption of laminin‐2–sulfatide interactions impeded OLG differentiation and myelin‐like membrane formation. On laminin‐2, but not on (re)myelination‐inhibiting fibronectin, su…

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Sulfatide‐mediated control of extracellular matrix‐dependent oligodendrocyte maturation

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