Wednesday July 26th 2017

The pill times 2: What every woman with multiple sclerosis should know

Until fingolimod came along, the first Food and Drug Administration–approved pill for relapsing-remitting multiple sclerosis (RRMS), teratogenicity of multiple sclerosis (MS) drugs had not been a big issue. Strange, for a disease that affects primarily women of childbearing age. Why? Because previously approved MS drugs were all large recombinant protein molecules. Large molecules cross the placenta by active transport, an issue for natalizumab (a monoclonal antibody), but only after the first trimester, during which the critical periods for organogenesis have been completed. The most commonly used self-injectables (β-interferons and glatiramer acetate) are barely detectable in the circulation and have no known active transport mechanisms. Then came fingolimod, a pill that requi…

Original post – 

The pill times 2: What every woman with multiple sclerosis should know

Leave a Comment

More from category

Gait and cognitive impairments in multiple sclerosis: the specific contribution of falls and fear of falling – Kalron A, Allali G.
Gait and cognitive impairments in multiple sclerosis: the specific contribution of falls and fear of falling – Kalron A, Allali G.

Our goal was to identify the specific contribution of fear of falling (FoF) and falls with quantitative gait [Read More]

12 National Patient Advocacy Organizations Urge Senate to Vote “No” on Advancing ACA Repeal, Urging
12 National Patient Advocacy Organizations Urge Senate to Vote “No” on Advancing ACA Repeal, Urging

/About-the-Society/News/12-National-Patient-Advocacy-Organizations-Urge-Se [Read More]

Low vitamin D may affect recovery of injured corneas
Low vitamin D may affect recovery of injured corneas

Injury or disease in combination with too little vitamin D can be bad for the window to your eyes. The three-layer, [Read More]

CUMC researchers capture first snapshot of key brain receptor in action
CUMC researchers capture first snapshot of key brain receptor in action

Columbia University Medical Center researchers have captured the first three-dimensional snapshots of the AMPA-subtype [Read More]

Contact Your Senators About Health Care
Contact Your Senators About Health Care

/About-the-Society/News/Contact-Your-Senators-About-Health-Care [Read More]