Wednesday July 26th 2017

The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes

The family of interleukin 17 receptors (IL17Rs), subtypes IL17RA‐IL17RE, is targeted by the group of pro‐inflammatory IL17 cytokines (IL17A‐F) and moreover the newly developed anti‐IL17A antibody secukinumab (AIN457) has shown promise in Phase II trials in multiple sclerosis. Here, we show that human astrocytes, isolated from a fetal cerebral cortex, express IL17RA and IL17RC and in vitro treatment with IL17A increases protein levels of IL6 in human astrocytes, which is enhanced in the presence of TNFα, as determined by homogeneous time resolved fluorescence. Studies on acutely isolated mouse astrocytes are comparable to human astrocytes although the protein levels of IL6 are lower in mouse astrocytes, which also show a lower response to IL17F and IL1β in promoting IL6 levels. In…

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The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes

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