Saturday January 20th 2018

The two faces of neuromyelitis optica

Over the past 15 years, it had seemed as if neuromyelitis optica (NMO) might be a distinct and homogeneous subtype of CNS demyelinating disease distinguishable from the heterogeneous assortment of patients captured by the umbrella diagnosis of “multiple sclerosis (MS).” NMO had distinctive clinical, radiologic, and pathologic characteristics and, in most cases, a highly specific biomarker, aquaporin-4 (AQP4) autoantibodies, was detectable.1 However, recent observations might be interpreted as dashing hopes of NMO being a single disorder with uniform pathogenesis. The clinical presentation of NMO is increasingly recognized as heterogeneous. A variety of cerebral, diencephalic, and brainstem presentations1,2 may occur as presenting features or over the course of the disease, which may have b…

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The two faces of neuromyelitis optica

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