Wednesday September 20th 2017

12. Co-existence of primary progressive MS and CMT1A

A 48-year old man presented with a 20-year history of neurological symptoms. He reported slowly progressive changes in gait, mild right leg weakness and subtle short-term memory problems. There was no history of discrete relapses and no family history of neurological disease. The neurological examination revealed upper and lower limb weakness, marked lower limb spasticity, globally brisk reflexes and extensor plantar responses.MRI of the brain demonstrated white matter T2/FLAIR hyperintensities with extensive pericallosal involvement and MRI of the spinal cord revealed lesions in the thoracic cord suggestive of demyelination. Somatosensory and visual evoked potentials were markedly delayed and oligoclonal bands were detected in cerebrospinal fluid, consistent with multiple sclerosis. Nerve…

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12. Co-existence of primary progressive MS and CMT1A

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