Saturday May 27th 2017

7. Effects of fampridine PR on axonal function in multiple sclerosis

Objective: Fampridine PR (prolonged-release 4-aminopyridine tablets) is a treatment for walking disability in multiple sclerosis (MS). While 4-aminopyridine is known to block kV 1.1 potassium channels in vitro, the mechanisms underlying its beneficial effects in the clinical setting have not been investigated. The aim of the present study was to investigate the effects of fampridine on axonal function in an MS cohort.Methods: Studies were conducted on 13 MS patients and 29 aged-matched controls. Studies were conducted at baseline and 6weeks following the commencement of fampridine PR 10mg b.d. Axonal function was assessed using nerve excitability techniques, which provide information on axonal ion channel function and membrane potential. Neurophysiological parameters were correlated with c…

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7. Effects of fampridine PR on axonal function in multiple sclerosis

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