Wednesday July 26th 2017

Blocking initial infiltration of pioneer CD8+ T‐cells into the CNS via inhibition of SHP‐2 ameliorates experimental autoimmune encephalomyelitis…

Conclusions and ImplicationsNSC‐87877 almost completely abolished the development of EAE by blocking the initial infiltration of pioneer CD8+ T‐cells into the uninflamed CNS. These results reveal a critical role for SHP‐2 in regulating EAE pathogenesis and indicate that NSC‐87877 is a potential candidate for the treatment of relapsing‐remitting multiple sclerosis. (Source: British Journal of Pharmacology)

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Blocking initial infiltration of pioneer CD8+ T‐cells into the CNS via inhibition of SHP‐2 ameliorates experimental autoimmune encephalomyelitis…

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