Monday May 29th 2017

CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population

Conclusion: The genetic variations in CD58 may be associated with the susceptibility of NMO in a Korean population. Based on previous studies, we suspect that the A allele of rs2300747 may decrease CD58 RNA expression, thus increasing NMO risk. Also, we deduced that the G allele of rs1016140 caused an increase of T cell activity, which in turn eased the access of AQP4 antibody into central nervous system (CNS) and ultimately leading to NMO development. (Source: BioMed Central)

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CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population

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