Friday October 20th 2017

Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis.

Authors: Lin TH, Spees WM, Chiang CW, Trinkaus K, Cross AH, Song SK Abstract Optic neuritis is a frequent and early symptom of multiple sclerosis (MS). Conventional magnetic resonance (MR) techniques provide means to assess multiple MS-related pathologies, including axonal injury, demyelination, and inflammation. A method to directly and non-invasively probe white-matter function could further elucidate the interplay of underlying pathologies and functional impairments. Previously, we demonstrated a significant 27% activation-associated decrease in the apparent diffusion coefficient of water perpendicular to the axonal fibers (ADC⊥) in normal C57BL/6 mouse optic nerve with visual stimulation using diffusion fMRI. Here we apply this approach to explore the relationship between vis…

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Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis.

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