Wednesday September 20th 2017

Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with…

Abstract: Schizophrenia is a severe debilitating brain disorder with a poorly understood aetiology. Among the diverse aetiological clues lies evidence for immune abnormalities in some individuals. The aim of this study was to investigate the frequency and specificity of autoantibodies directed against the brain in people with schizophrenia. Sera were screened for reactivity against human brain tissue (hippocampus and prefrontal cortex). Neuronal cell body and filamentous patterns of brain tissue staining were observed significantly more frequently in sera from schizophrenia patients (n=30) compared to controls (n=24). Sera that showed a neuronal cell body pattern of staining on hippocampus reacted strongly to an extracellular epitope of the M1 muscarinic acetylcholine receptor (m1AChR) in …

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Taken from: 

Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with…

Leave a Comment

More from category

New man-made antioxidant could help improve success rates of cell-based therapies
New man-made antioxidant could help improve success rates of cell-based therapies

Cell therapies being developed to treat a range of conditions could be improved by a chemical compound that aids their [Read More]

Patient and Provider Organizations Oppose Graham-Cassidy Health Care Proposal
Patient and Provider Organizations Oppose Graham-Cassidy Health Care Proposal

/About-the-Society/News/Patient-and-Provider-Organizations-Oppose-Graham-C [Read More]

Researchers Discover Potential Driver of MS Disease Progression and Test Ways to Block It
Researchers Discover Potential Driver of MS Disease Progression and Test Ways to Block It

/About-the-Society/News/Researchers-Discover-Potential-Driver-of-MS-Diseas [Read More]

Scientists discover markers for progressive multiple sclerosis
Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- [Read More]

Study uncovers markers for severe form of multiple sclerosis
Study uncovers markers for severe form of multiple sclerosis

Scientists have uncovered two molecules involved in cell communication and movement that may explain why some people [Read More]