Saturday December 16th 2017

Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury.

In this study we show that levels of APP, the enzymes cleaving APP (Bace1 and γ-secretase), and Aβ are significantly increased from 1 to 3 days after impact spinal cord injury (SCI) in mice. To determine the role of Aβ after SCI, we reduced or inhibited Aβ in vivo through pharmacological (using DAPT) or genetic (Bace1 knockout mice) approaches. We found that these interventions significantly impaired functional recovery as evaluated by white matter sparing and behavioral testing. These data are consistent with a beneficial role for Aβ after SCI. PMID: 24630972 [PubMed – as supplied by publisher] (Source: Brain Research)

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Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury.

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