Thursday January 18th 2018

Regulatory T-cell vaccination independent of auto-antigen.

Authors: Pascual DW, Yang X, Holderness K, Jun S, Maddaloni M, Kochetkova I Abstract To date, efforts to treat autoimmune diseases have primarily focused on the disease symptoms rather than on the cause of the disease. In large part, this is attributed to not knowing the responsible auto-antigens (auto-Ags) for driving the self-reactivity coupled with the poor success of treating autoimmune diseases using oral tolerance methods. Nonetheless, if tolerogenic approaches or methods that stimulate regulatory T (Treg) cells can be devised, these could subdue autoimmune diseases. To forward such efforts, our approach with colonization factor antigen I (CFA/I) fimbriae is to establish bystander immunity to ultimately drive the development of auto-Ag-specific Treg cells. Using an attenuated…

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Regulatory T-cell vaccination independent of auto-antigen.

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