Monday May 29th 2017

Therapeutic Plasma Exchange in Glucocorticosteroid‐Unresponsive Patients With Clinically Isolated Syndrome

Abstract Clinically Isolated Syndromes (CIS) summarize clinical features of possible multiple sclerosis (MS) as a first clinical event of the disease. Escalation therapy in CIS episodes comprises high dose glucocorticosteroid (GCS) treatment followed by therapeutic plasma exchange (TPE) in patients unresponsive to GCS. The aim of our study was to analyze TPE effects in CIS patients. Eleven GCS‐unresponsive patients exhibiting CIS were treated with TPE. A median of 5.0 (range 3–8) treatments were performed with a median exchange volume of 3.0 L (range 2.2–3.5 L). Standard diagnostic results in CIS patients were collected. In 10 out of 11 patients clinical improvement was observed. In Expanded Disability Status Scale (EDSS) Scoring, a commonly used score to assess disability in MS …

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Therapeutic Plasma Exchange in Glucocorticosteroid‐Unresponsive Patients With Clinically Isolated Syndrome

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