Monday January 22nd 2018

B Cells from Blood of Patients with Relapsing-Remitting Multiple Sclerosis Induce Apoptosis in Neurons In Vitro (P1.177)

CONCLUSIONS: MS B cell Sup induce neuronal death to a much greater extent than NC Sup. Neuronal death was independent of IgG and IgM, not mediated by complement activation and occurred at least partially by apoptosis. B cells found in the meninges could be particularly important in mediating demyelination and neuronal/axonal damage in subpial cortical MS lesions.Study Supported by: Parker Webber Endowment (WSU/DMC Foundation); Mary Parker Neuroscience Fund (DMC Foundation); Multiple Sclerosis Society of Canada; Canadian Institutes of Health ResearchDisclosure: Dr. Lisak has received personal compensation for activities with Teva Neuroscience, Bayer Pharmaceuticals Corp., Avanir Pharmaceuticals, and Questcor Diagnostics. Dr. Lisak has received personal compensation in an editorial capacity …

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B Cells from Blood of Patients with Relapsing-Remitting Multiple Sclerosis Induce Apoptosis in Neurons In Vitro (P1.177)

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