Saturday May 27th 2017

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

In conclusion, we provide for the first time a comprehensive overview of key nutrient transporters in white matter brain samples. Moreover, our data demonstrate an altered expression of these nutrient transporters in MS brain tissue, including a marked reduction of axonal GLUT3 and MCT2 expression in chronic lesions, which may impede efficient nutrient supply to the hypoxic demyelinated axons thereby contributing to the ongoing neurodegeneration in MS. GLIA 2014 (Source: Glia)

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Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

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