Friday December 15th 2017

Cytokine Influence on Oligodendrocyte Progenitor Cell Proliferation (P1.157)

CONCLUSIONS: Inhibition of OPC proliferation, an essential step preceding myelination and remyelination, follows exposure to both IL1 and IL2, using defined culture medium. Neither cytokine alone limits OPC proliferation. This data indicates a potential mechanism restricting remyelination in MS, whether mediated through endogenous OPCs or transferred stem cells. Targeting these local factors impacting OPC proliferation may provide more precise therapy, with fewer systemic side effects, than contemporary systemic treatment approaches to inflammatory mediated demyelinating disease.Study Support: None.Disclosure: (Source: Neurology)

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Cytokine Influence on Oligodendrocyte Progenitor Cell Proliferation (P1.157)

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