Thursday December 14th 2017

Deficiency of Brain Heme Oxygenase-1 in HIV-Infected Individuals: Potential Target for Adjunctive Therapy (P4.306)

CONCLUSIONS:HIV infection reduces CNS HO-1 protein expression and this deficiency may play a role in neuroinflammation and neurocognitive impairment in HAND patients. HO-1 is a targetable neuroprotective host factor that modulates macrophage-mediated neurodegeneration in HIV infection. Therapeutic inducers of HO-1 including dimethyl fumarate, which was recently approved by the FDA for the treatment of multiple sclerosis, should be studied further for their potential clinical efficacy in reducing the prevalence of HAND in ART-treated individuals.Study Supported by:NS043994 (DLK), MH095671 (DLK), and NS072005 (BBG)Disclosure: Dr. Gill has nothing to disclose. Dr. Ambegaokar has nothing to disclose. Dr. Kovacsics has nothing to disclose. Dr. Cross has nothing to disclose. Dr. Gelman has nothi…

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Deficiency of Brain Heme Oxygenase-1 in HIV-Infected Individuals: Potential Target for Adjunctive Therapy (P4.306)

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