Friday December 15th 2017

Differential Impact Of Natalizumab And Fingolimod On The alpha-4/beta-1 Expression-Related Subset Diversity Of T Cells (P1.197)

CONCLUSIONS: Natalizumab acts as a brake on the alpha-4 expression resulting in reduced frequencies of alpha-4/beta-1 coexpressing T cell subsets. The fingolimod-mediated redistribution of immune cells rather leads to a relative increase in the frequencies of naive alpha-4+/beta-1+ T cells. This raises the question if an extensive subset analysis between patient groups might allow differentiating disease-promoting cells from those required for immune surveillance.Disclosure: Dr. Kraus has received personal compensation for activities with Allmirall, Bayer Pharmaceuticals Corp., Biogen Idec, Genzyme Corp., Medtronic Inc., Merck Serono, Novartis, and Sanofi-Avent Pharmaceuticals Inc. Dr. Oppermann has received personal compensation for activities with Merck & Co. Inc., and Sanofi-Aventis…

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Differential Impact Of Natalizumab And Fingolimod On The alpha-4/beta-1 Expression-Related Subset Diversity Of T Cells (P1.197)

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