Friday December 15th 2017

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1.204)

CONCLUSIONS:These studies demonstrate that DMF and MEF are both pharmacologically active, but have differing degrees of activities in multiple assay formats. These differences would be expected to result in divergent effects on downstream biology.Study Supported by:Biogen Idec Inc.Disclosure: Dr. Scannevin has received personal compensation for activities with Biogen Idec as an employee. Dr. Scannevin holds stock and/or stock options in Biogen Idec which sponsored research in which Dr. Scannevin was involved as an investigator. Dr. Brennan has received personal compensation for activities with Biogen Idec as an employee. Dr. Matos has received personal compensation for activities with Biogen Idec as an employee. Dr. Hronowski has received personal compensation for activities with Biogen Id…

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Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1.204)

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