Monday December 18th 2017

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Pharmacodynamic Effects and Pharmacokinetics In Vivo (P1.207)

CONCLUSIONS:DMF/MMF and MEF were absorbed to a similar degree after oral dosing, however there were biodistribution differences, most notably in brain and kidney. Both compounds alone or in combination were active in vivo, with some common responses and others distinct to each treatment. The data indicate that all fumaric acid esters cannot be each considered equivalent, and combinations of compounds may exert effects not observed when agents are used individually.Study Supported by:Biogen Idec Inc.Disclosure: Dr. Scannevin has received personal compensation for activities with Biogen Idec as an employee. Dr. Scannevin holds stock and/or stock options in Biogen Idec which sponsored research in which Dr. Scannevin was involved as an investigator. Dr. Szak has received personal compensation …

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Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Pharmacodynamic Effects and Pharmacokinetics In Vivo (P1.207)

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