Sunday November 19th 2017

Early netrin‐1 expression impairs central nervous system remyelination

Abstract Objective: Chronically demyelinated multiple sclerosis (MS) lesions are frequently characterized by scarce undifferentiated oligodendrocyte progenitor cells (OPCs) suggesting the exhaustion of a local OPC pool followed by failure of recruitment and differentiation. Stimulating prompt OPC recruitment following demyelination could improve myelin repair by providing sufficient numbers of remyelinating cells during the “repair‐permissive” period. Understanding mechanisms that determine this process may have important therapeutic implications. We therefore investigated the role of the guidance molecule netrin‐1 in OPC recruitment and CNS remyelination. Methods: Netrin‐1 expression was analysed immunohistochemically in different types of MS lesions and in the murine lysolecith…

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Early netrin‐1 expression impairs central nervous system remyelination

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