Saturday December 16th 2017

Fatigue and Functional MRI in Multiple Sclerosis: A Quantitative Coordinate-based Activation Likelihood Estimation Meta-Analysis (P3.051)

CONCLUSIONS. Our most robust finding is that brain regions are consistently more active in MS patients with fatigue than in controls. The patterns of activation in response to a task are highly variable in the presence of fatigue. Activation heterogeneity suggests that fatigue assessment tools are far from being able to provide a reproducible measure for inclusion in fMRI studies. Future fMRI studies should use a ‘multi-tiered’ approach to include also structures beyond, but functionally linked, to the thalamo-cortical loop.Disclosure: Dr. Tanasescu has nothing to disclose. Dr. Constantinescu has received personal compensation for activities with Biogen Idec, Teva Neuroscience, and Novartis. Dr. Constantinescu has received research support from Serono Inc., Biogen Idec, Teva Neuroscience, …

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Fatigue and Functional MRI in Multiple Sclerosis: A Quantitative Coordinate-based Activation Likelihood Estimation Meta-Analysis (P3.051)

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