Saturday December 16th 2017

Fgfr1 Ablation In Oligodendrocytes Reduces Disease Severity And Inflammation In The CNS In MOG35-55 Induced EAE (P1.167)

CONCLUSIONS:Our results suggest that the Fgfr1 in oligodendrocytes negatively influences the disease course of chronic EAE. The underlying mechanism could be that the Fgfr1 blockade results in reduced costimulation of T-cells as well as other inflammatory cells in the CNS. Since cytokine expression is not changed, other mechanisms such as neuronal growth factors or alternative cell proliferation pathways may explain the reduced inflammation.Study Supported by:This study was supported by MERCK Serono.Disclosure: Dr. Rajendran has nothing to disclose. Dr. Giraldo Velasquez has nothing to disclose. Dr. Stadelmann-Nessler has received personal compensation for activities with Teva Neuroscience. Dr. Berghoff has received personal compensation for activities with Bayer Pharmaceuticals Corporatio…

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Fgfr1 Ablation In Oligodendrocytes Reduces Disease Severity And Inflammation In The CNS In MOG35-55 Induced EAE (P1.167)

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