Thursday December 14th 2017

Immunoregulation during Multiple Sclerosis Relapses. Effects of Intravenous Methylprednisolone. (P1.208)

CONCLUSIONS: All together, these data suggest that specific anti-inflammatory responses are activated during a MS relapse. IvMP treatment might strengthen these mechanisms without increasing Treg frequency. We are currently studying the expression of the aryl hydrocarbon receptor (AHR). This transcription factor is a crucial link between environmental factors and host immune function and plays a critical role in IL-22 and CD39 production. Preliminary experiments show that ivMP increases AHR mRNA expression. Identifying pathways promoting anti-inflammatory responses is of interest for the treatment of relapsing MS.Study Supported by the Charcot Foundation and the Walloon Region “Désordres Inflammatoires dans les Affections Neurologiques” project.Disclosure: Dr. Van Pesch has received…

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Immunoregulation during Multiple Sclerosis Relapses. Effects of Intravenous Methylprednisolone. (P1.208)

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