Friday December 15th 2017

Interferon Beta Assessment in Non-Chinese and Chinese Subjects: Pharmacokinetics and Pharmacodynamic Activity of an Endogenous Cytokine Are Not Race…

In this study, 24 healthy Chinese subjects (11 male, 13 female) each received 4 once-weekly 60-mcg IM doses of IFNβ-1a. Serial blood samples were drawn for PK and pharmacodynamic (PD) assessments following the first and last dose of drug. Results were compared with historical data from a recent PK/PD assessment conducted in non-Chinese subjects. Noncompartmental analysis revealed that no meaningful differences in either IFNβ-1a exposure or response were apparent between the Chinese and non-Chinese populations. Thus, it was concluded that no adjustment in dose regimen is warranted for future assessments of safety and efficacy in multiple sclerosis patients of Chinese origin. PMID: 24737408 [PubMed – as supplied by publisher] (Source: The Journal of Clinical Pharmacology)

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Interferon Beta Assessment in Non-Chinese and Chinese Subjects: Pharmacokinetics and Pharmacodynamic Activity of an Endogenous Cytokine Are Not Race…

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